News and Release Notes

a timeline of updates to cryoDRGN

Use commands such as `pip install 'cryodrgn==3.4.3'` (replacing with your preferred version number) to install a specific past version of cryoDRGN!

Release Timeline

  • 09/2025: cryodrgn version v3.5.2 released, with faster backprojection through batched data processing, faster downsampling through I/O threading, and faster reconstruction when using larger default batch sizes

  • 08/2025: cryodrgn version v3.5.1 released, with new --force-ntilts to only include particles with x available tilts in backproject_voxel, plotting classes in z-latent-space using scatterplots, and fixing bug with ragged tilt-series inputs to interactive filtering

  • 08/2025: cryodrgn version v3.5.0 released, with 1-indexing for output volumes and epochs, train_dec for reconstruction with an auto-decoder, automatic analyze executed on the last epoch of training, and a unified parse_star command

  • 04/2025: cryodrgn version v3.4.4 released, with new support for Python 3.12, as well as introducing --shuffle-seed to fix randomness of batch iteration during training

  • 12/2024: cryodrgn version 3.4.3 released, adding a utility make_movies for animations of volumes created by cryoDRGN models, as well improving the interactive filtering interface

  • 11/2024: cryodrgn version 3.4.2 released, adding auto mixed-precision training to ab-initio reconstruction for faster training, alongside speedups to parse_pose_star and analyze_landscape_full

  • 10/2024: cryodrgn version 3.4.1 released, adding support for float16-formatted input .mrcs image stacks and addressing issues with downsample, filter, and volume evaluation

  • 09/2024: cryodrgn version 3.4.0 released, introducing plotting by class labels, support for RELION 3.1, and calculation of phase-randomized Fourier Shell correlations

  • 06/2024: cryodrgn version 3.3.3 released, addressing issues in backproject, write_star, and filter

  • 05/2024: cryodrgn version 3.3.2 released with improvements and fixes made to several features, including filtering with notebooks, FSC plots in backproject_voxel, and support for RELION 3.1 inputs in parse_pose_star

  • 04/2024: cryodrgn version 3.3.0 released — first non-beta release of cryoDRGN-ET, new command cryodrgn direct_traversal, improved testing, and cleaned-up Jupyter notebooks

  • 03/2024: cryodrgn version 3.2.0-beta released with new commands including cryodrgn_utils clean, cryodrgn_utils gen_mask, and cryodrgn_utils fsc

  • 12/2023: cryodrgn version 3.1.0-beta released with new command cryodrgn filter for interactive filtering of particles

  • 09/2023: CryoDRGN-ET for subtomogram analysis is now available in beta, as cryodrgn version 3.0.0-beta

  • 06/2023: documentation clean up, available here on gitbook

  • 05/2023: cryodrgn version 2.3.0 released with improvements and fixes to ab initio tools.

  • 01/2023: cryodrgn version 2.2.0 released with new ab initio reconstruction tools and more.

  • 07/2022: cryodrgn version 1.1.0 released with updated default architecture

  • 05/2022: cryodrgn version 1.0.0 released with new landscape analysis, cryodrgn_utils, and more

Software Change Log

Comprehensive notes on all releases including minor and patch versions can be found at the Github repository: https://github.com/zhonge/cryodrgn/releases

Documentation Change Log

Last updated